STIMULATION OF ADULT CHONDROCYTE METABOLISM BY A THYROID-DERIVED FACTOR

被引：26

作者：

JONES, DG ^{[1
]}

SMITH, RL ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,ORTHOPAED RES LAB,R171,300 PASTEUR DR,STANFORD,CA 94305

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 1990年 / 8卷 / 02期

关键词：

Adult articular chondrocytes; Calcitonin; Cell proliferation; Glycosaminoglycan; Thyrocalcitonin; Thyroid hormones;

D O I：

10.1002/jor.1100080211

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

This paper reports the effects of adding partially purified bovine thyroid calcitonin, thyrocalcitonin, to adult bovine articular cartilage cells. Thyrocalcitonin stimulated chondrocyte proliferation fourfold under low serum (0.5%) culture conditions. In serum‐free medium, thyrocalcitonin stimulated cell proliferation more than twofold. With high‐density cultures in serum‐free medium, chondrocyte glycosaminoglycan (GAG) synthesis was stimulated 60% by thyrocalcitonin. Cell‐associated radioactivity was increased twofold. In contrast to thyrocalcitonin, addition of human and salmon calcitonin peptides as well as the thyroid hormones T3 and T4 had no effect on adult cartilage cell proliferation or GAG synthesis. The data reported here suggest the existence of a thyroid‐derived factor, independent of calcitonin peptides or thyroid hormones, which stimulates adult articular chondrocyte metabolism. Copyright © 1990 Orthopaedic Research Society

引用

页码：227 / 233

页数：7

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