ANTIMYCOBACTERIAL ACTIVITY OF A SERIES OF PYRAZINOIC ACID-ESTERS

被引：86

作者：

CYNAMON, MH

KLEMENS, SP

CHOU, TS

GIMI, RH

WELCH, JT

机构：

[1] SUNY HLTH SCI CTR,SYRACUSE,NY 13210

[2] SUNY ALBANY,DEPT CHEM,ALBANY,NY 12222

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 07期

关键词：

D O I：

10.1021/jm00085a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pyrazinoic acid esters has been prepared and evaluated for in vitro antimycobacterial activity. Several of the pyrazinoate esters have substantially better activity than the first-line antituberculous agent pyrazinamide against susceptible isolates of Mycobacterium tuberculosis as well as activity against pyrazinamide-resistant isolates. The minimal inhibitory concentrations (MICs) were lower for each organism and at each pH than the MICs for pyrazinamide. The esters have activity against Mycobacterium bovis and Mycobacterium kansasii, two species resistant to pyrazinamide, but not against Mycobacterium avium complex.

引用

页码：1212 / 1215

页数：4

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