MUTATIONS OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR THAT CAUSE A LOSS OF LIGAND-INDUCED CONFORMATIONAL CHANGE, SUBTLE CHANGES IN KINASE-ACTIVITY, AND IMPAIRED ABILITY TO STIMULATE DNA-SYNTHESIS

被引：84

作者：

FANTL, WJ ^{[1
]}

ESCOBEDO, JA ^{[1
]}

WILLIAMS, LT ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,CARDIOVASC RES INST,DEPT MED,SAN FRANCISCO,CA 94143

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1989年 / 9卷 / 10期

关键词：

D O I：

10.1128/MCB.9.10.4473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：4473 / 4478

页数：6

共 27 条

[1] A NEW ACUTE TRANSFORMING FELINE RETROVIRUS AND RELATIONSHIP OF ITS ONCOGENE V-KIT WITH THE PROTEIN-KINASE GENE FAMILY [J].

BESMER, P ;

MURPHY, JE ;

GEORGE, PC ;

QIU, F ;

BERGOLD, PJ ;

LEDERMAN, L ;

SNYDER, HW ;

BRODEUR, D ;

ZUCKERMAN, EE ;

HARDY, WD .

NATURE, 1986, 320 (6061) :415-421

[2] STRUCTURAL ALTERATION OF VIRAL HOMOLOG OF RECEPTOR PROTOONCOGENE FMS AT CARBOXYL TERMINUS [J].

COUSSENS, L ;

VANBEVEREN, C ;

SMITH, D ;

CHEN, E ;

MITCHELL, RL ;

ISACKE, CM ;

VERMA, IM ;

ULLRICH, A .

NATURE, 1986, 320 (6059) :277-280

[3] REPLACEMENT OF INSULIN-RECEPTOR TYROSINE RESIDUE-1162 AND RESIDUE-1163 DOES NOT ALTER THE MITOGENIC EFFECT OF THE HORMONE [J].

DEBANT, A ;

CLAUSER, E ;

PONZIO, G ;

FILLOUX, C ;

AUZAN, C ;

CONTRERES, JO ;

ROSSI, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :8032-8036

[4]

EK B, 1982, J BIOL CHEM, V257, P486

[5] A PDGF RECEPTOR DOMAIN ESSENTIAL FOR MITOGENESIS BUT NOT FOR MANY OTHER RESPONSES TO PDGF [J].

ESCOBEDO, JA ;

WILLIAMS, LT .

NATURE, 1988, 335 (6185) :85-87

[6] ROLE OF TYROSINE KINASE AND MEMBRANE-SPANNING DOMAINS IN SIGNAL TRANSDUCTION BY THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR [J].

ESCOBEDO, JA ;

BARR, PJ ;

WILLIAMS, LT .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (12) :5126-5131

[7]

ESCOBEDO JA, 1988, J BIOL CHEM, V263, P1482

[8]

FRACKELTON AR, 1984, J BIOL CHEM, V259, P7909

[9] 2 CLASSES OF PDGF RECEPTOR RECOGNIZE DIFFERENT ISOFORMS OF PDGF [J].

HART, CE ;

FORSTROM, JW ;

KELLY, JD ;

SEIFERT, RA ;

SMITH, RA ;

ROSS, R ;

MURRAY, MJ ;

BOWENPOPE, DF .

SCIENCE, 1988, 240 (4858) :1529-1531

[10] BINDING OF DIFFERENT DIMERIC FORMS OF PDGF TO HUMAN-FIBROBLASTS - EVIDENCE FOR 2 SEPARATE RECEPTOR TYPES [J].

HELDIN, CH ;

BACKSTROM, G ;

OSTMAN, A ;

HAMMACHER, A ;

RONNSTRAND, L ;

RUBIN, K ;

NISTER, M ;

WESTERMARK, B .

EMBO JOURNAL, 1988, 7 (05) :1387-1393

← 1 2 3 →