DEXTRAN PERMEATION THROUGH POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS

被引：37

作者：

DONG, LC ^{[1
]}

HOFFMAN, AS ^{[1
]}

YAN, Q ^{[1
]}

机构：

[1] UNIV WASHINGTON,CTR BIOENGN FL20,SEATTLE,WA 98195

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 1994年 / 5卷 / 05期

关键词：

FITC-DEXTRAN; PERMEATION; HYDROGEL; PORE SIZE; POLY(N-ISOPROPYLACRYLAMIDE); DIFFUSION; THERMALLY REVERSIBLE;

D O I：

10.1163/156856294X00158

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The permeation of macromolecules such as fluoroescein-labeled dextran fractions through thermally reversible hydrogels has been investigated. A permeation model has been formulated, which takes into account hydrogel porosity and tortuosity as well as the combined effect of a geometric restraint for a relatively large solute molecule at a pore entrance and the friction between solute molecules moving through the pores and pore walls. Based on this model, we have estimated the tortuosity and average pore size of a swollen hydrogel, poly(N-isopropylacrylamide) [poly(NIPAAm)] and a swollen heterogel, poly(N-isopropylacrylamide-co-vinyl-terminated dimethylsiloxane) [poly(NIPAAm-co-VTPDMS)]. The permeation data for dextran molecules up to the size of 43.5 Angstrom in radius show good agreement with the values predicted from the model.

引用

页码：473 / 484

页数：12

共 19 条

[1] HINDERED DIFFUSION IN MICROPOROUS MEMBRANES WITH KNOW PORE GEOMETRY [J].