EFFECT OF CONTINUOUS ARTERIOVENOUS HEMOFILTRATION ON PHARMACOKINETICS OF AMRINONE

被引：5

作者：

LAWLESS, S

RESTAINO, I

AZIN, S

CORDDRY, D

机构：

[1] ALFRED I DUPONT INST,DEPT PEDIAT,WILMINGTON,DE 19899

[2] THOMAS JEFFERSON UNIV,WILMINGTON,DE

来源：

CLINICAL PHARMACOKINETICS | 1993年 / 25卷 / 01期

关键词：

D O I：

10.2165/00003088-199325010-00006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This case report details the pharmacokinetic adjustments of an amrinone infusion in a paediatric patient who developed multiorgan system failure with anuric renal failure and was prescribed continuous arteriovenous haemofiltration. A significant proportion of clearance of amrinone is nonrenal. Near normal amrinone clearance can occur in patients with hepatic and renal dysfunction if continuous arteriovenous haemofiltration is used. Hepatic dysfunction with renal failure may require a reduction in the continuous amrinone infusion rate as previously reponed for neonates.

引用

页码：80 / 82

页数：3

共 7 条

[1]

BICKLEY SK, 1988, CLIN PHARMACY, V7, P198

[2] AMRINONE METABOLISM [J].