TRENDS IN THE SEARCH FOR BIOACTIVE MICROBIAL METABOLITES

被引:43
作者
OMURA, S
机构
[1] Research Center for Biological Function, The Kitasato Institute, Tokyo, 108, 5-9-1 Shirokane, Minatoku
来源
JOURNAL OF INDUSTRIAL MICROBIOLOGY | 1992年 / 10卷 / 3-4期
关键词
MICROBIAL METABOLITE; SCREENING; MOTILIDE; PROTEIN KINASE; AVERMECTIN; ACAT; KITASATOSPORIA; TRIACSIN; HMG-COA SYNTHASE; STAUROSPORINE;
D O I
10.1007/BF01569759
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Bioactive microbial metabolites are attracting increasing attention as useful agents for medicine, veterinary medicine, agriculture, and as unique biochemical tools. A review of the current trends in the discovery of new metabolites shows that the number of active compounds with non-antibiotic type of activity has increased, resulting in an expansion of the variety of bioactivity of microbial metabolites. Factors that contribute to the increased rate of discovery include: development of new methods for activity measurement, exploitation of novel groups of microorganisms as sources of active compounds, new directions for chemical modification, and incorporation of newer knowledge of biotechnology into screening systems. To exemplify this, typical screening methods, and chemical and biological properties of several bi active compounds obtained by these methods are discussed.
引用
收藏
页码:135 / 156
页数:22
相关论文
共 139 条
[91]   NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION [J].
OMURA, S ;
IWAI, Y ;
HIRANO, A ;
NAKAGAWA, A ;
AWAYA, J ;
TSUCHIYA, H ;
TAKAHASHI, Y ;
MASUMA, R .
JOURNAL OF ANTIBIOTICS, 1977, 30 (04) :275-282
[92]   TYPE OF DIAMINOPIMELIC ACID DIFFERENT IN AERIAL AND VEGETATIVE MYCELIA OF SETAMYCIN-PRODUCING ACTINOMYCETE KM-6054 [J].
OMURA, S ;
IWAI, Y ;
TAKAHASHI, Y ;
KOJIMA, K ;
OTOGURO, K ;
OIWA, R .
JOURNAL OF ANTIBIOTICS, 1981, 34 (12) :1633-1634
[93]   PHILOSOPHY OF NEW DRUG DISCOVERY [J].
OMURA, S .
MICROBIOLOGICAL REVIEWS, 1986, 50 (03) :259-279
[94]   AGGRECERIDE, A NEW PLATELET-AGGREGATION INHIBITOR FROM STREPTOMYCES [J].
OMURA, S ;
NAKAGAWA, A ;
FUKAMACHI, N ;
OTOGURO, K ;
KOBAYASHI, B .
JOURNAL OF ANTIBIOTICS, 1986, 39 (08) :1180-1181
[95]   PRODUCTION OF NEW HYBRID ANTIBIOTICS, MEDERRHODIN-A AND MEDERRHODIN-B, BY A GENETICALLY ENGINEERED STRAIN [J].
OMURA, S ;
IKEDA, H ;
MALPARTIDA, F ;
KIESER, HM ;
HOPWOOD, DA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (01) :13-19
[96]   AHPATININS, NEW ACID PROTEASE INHIBITORS CONTAINING "4-AMINO-3-HYDROXY-5-PHENYLPENTANOIC ACID [J].
OMURA, S ;
IMAMURA, N ;
KAWAKITA, K ;
MORI, Y ;
YAMAZAKI, Y ;
MASUMA, R ;
TAKAHASHI, Y ;
TANAKA, H ;
HUANG, LY ;
WOODRUFF, HB .
JOURNAL OF ANTIBIOTICS, 1986, 39 (08) :1079-1085
[97]  
OMURA S, 1988, BIOL ACTINOMYCETES 8, P26
[98]  
OMURA S, 1990, MOTILIN, P245
[99]   A NEW INHIBITOR OF PROTEIN-KINASE-C, RK-1409 (7-OXOSTAUROSPORINE) .1. TAXONOMY AND BIOLOGICAL-ACTIVITY [J].
OSADA, H ;
KOSHINO, H ;
KUDO, T ;
ONOSE, R ;
ISONO, K .
JOURNAL OF ANTIBIOTICS, 1992, 45 (02) :189-194
[100]   NATURALLY-OCCURRING MONOBACTAMS [J].
PARKER, WL ;
OSULLIVAN, J ;
SYKES, RB .
ADVANCES IN APPLIED MICROBIOLOGY, 1986, 31 :181-205