VIRUS-INDUCED VS ENDOTOXIN-INDUCED ACTIVATION OF LIVER MACROPHAGES

被引:29
作者
BUSAM, KJ
HOMFELD, A
ZAWATZKY, R
KASTNER, S
BAUER, J
GEROK, W
DECKER, K
机构
[1] UNIV FREIBURG, INST BIOCHEM, HERMANN HERDER STR 7, W-7800 FREIBURG, GERMANY
[2] UNIV FREIBURG, MED KLIN, W-7800 FREIBURG, GERMANY
[3] GERMAN CANC RES CTR, INST VIRUSFORSCH, W-6900 HEIDELBERG 1, GERMANY
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1990年 / 191卷 / 03期
关键词
D O I
10.1111/j.1432-1033.1990.tb19160.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The response of liver macrophages (Kupffer cells) to distinct pathogenic material was investigated by comparing virus‐ and endotoxin‐induced macrophage activation. Endotoxin‐induced stimulation and induction with Newcastle disease virus (NDV) or Sendai virus led to the release of the same pattern of prostanoids characterized by a predominant production of prostaglandin E2 (PGE2). With respect to peptide mediators, hepatic macrophages secreted tumor necrosis factor‐α (TNF‐α) and interleukin‐6 after viral induction and endotoxin treatment, respectively. In response to viruses, however, much more interleukin‐6 and TNF‐α was detected than after endotoxin stimulation. Interferon type I (interferon‐α/β), on the other hand, was only detected in the supernatants of macrophages infected with viruses, but not of those exposed to endotoxin. This study also revealed that rat TNF‐α exists in several soluble species, some of which are glycosylated. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:577 / 582
页数:6
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