QUANTITATIVE-ANALYSIS OF STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS BY LINEAR FREE-ENERGY RELATIONSHIPS

被引：97

作者：

FERSHT, AR

LEATHERBARROW, RJ

WELLS, TNC

机构：

来源：

NATURE | 1986年 / 322卷 / 6076期

关键词：

D O I：

10.1038/322284a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：284 / 286

页数：3

共 10 条

[1] FERSHT A, 1985, ENZYME STRUCTURE MEC, pCH12
[2] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING
FERSHT, AR
SHI, JP
KNILLJONES, J
LOWE, DM
WILKINSON, AJ
BLOW, DM
BRICK, P
CARTER, P
WAYE, MMY
WINTER, G
[J]. NATURE, 1985, 314 (6008) : 235 - 238
[3] ANALYSIS OF ENZYME STRUCTURE AND ACTIVITY BY PROTEIN ENGINEERING
FERSHT, AR
SHI, JP
WILKINSON, AJ
BLOW, DM
CARTER, P
WAYE, MMY
WINTER, GP
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (07): : 467 - 473
[4] INTERNAL THERMODYNAMICS OF POSITION 51 MUTANTS AND NATURAL VARIANTS OF TYROSYL-TRANSFER RNA-SYNTHETASE
HO, CK
FERSHT, AR
[J]. BIOCHEMISTRY, 1986, 25 (08) : 1891 - 1897
[5] JENCKS WP, 1985, CHEM REV, V85, P511, DOI 10.1021/cr00070a001
[6] TRANSITION-STATE STABILIZATION IN THE MECHANISM OF TYROSYL-TRANSFER RNA-SYNTHETASE REVEALED BY PROTEIN ENGINEERING
LEATHERBARROW, RJ
FERSHT, AR
WINTER, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (23) : 7840 - 7844
[7] DELETION MUTAGENESIS USING AN M13 SPLINT - THE N-TERMINAL STRUCTURAL DOMAIN OF TYROSYL-TRANSFER RNA-SYNTHETASE (B-STEAROTHERMOPHILUS) CATALYZES THE FORMATION OF TYROSYL ADENYLATE
WAYE, MMY
WINTER, G
WILKINSON, AJ
FERSHT, AR
[J]. EMBO JOURNAL, 1983, 2 (10) : 1827 - 1829
[8] USE OF BINDING-ENERGY IN CATALYSIS ANALYZED BY MUTAGENESIS OF THE TYROSYL-TRANSFER RNA-SYNTHETASE
WELLS, TNC
FERSHT, AR
[J]. BIOCHEMISTRY, 1986, 25 (08) : 1881 - 1886
[9] HYDROGEN-BONDING IN ENZYMATIC CATALYSIS ANALYZED BY PROTEIN ENGINEERING
WELLS, TNC
FERSHT, AR
[J]. NATURE, 1985, 316 (6029) : 656 - 657
[10] REDESIGNING ENZYME STRUCTURE BY SITE-DIRECTED MUTAGENESIS - TYROSYL TRANSFER-RNA SYNTHETASE AND ATP BINDING
WINTER, G
FERSHT, AR
WILKINSON, AJ
ZOLLER, M
SMITH, M
[J]. NATURE, 1982, 299 (5885) : 756 - 758

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