CHARACTERIZATION OF CELL-LINES DERIVED FROM FORMALDEHYDE-INDUCED NASAL TUMORS IN RATS

被引：14

作者：

BERMUDEZ, E

CHEN, ZC

GROSS, EA

WALKER, CL

RECIO, L

PLUTA, L

MORGAN, KT

机构：

[1] Chemical Industry Institute of Toxicology, North Carolina, Research Triangle Park

[2] Cancer Research Institute, Hunan Medical University, Changsha, Hunan

[3] University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas

来源：

MOLECULAR CARCINOGENESIS | 1994年 / 9卷 / 04期

关键词：

TRANSFORMING GROWTH FACTOR-ALPHA; P53; ANEUPLOID;

D O I：

10.1002/mc.2940090403

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell lines derived from formaldehyde-induced nasal tumors in Fischer 344 rats were established. All of the lines were found to be epithelial and aneuploid and to express keratin, transforming growth factor-alpha, and epidermal growth factor receptor transcripts. Two of four lines were tumorigenic upon injection into nude mice, and these lines also contained point mutations in the p53 suppressor gene. The data indicate that these lines possess characteristics that make them a valuable tool for the study of chemically induced respiratory tract carcinogenesis. (C) 1994 Wiley-Liss, Inc.

引用

页码：193 / 199

页数：7

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