GASTRIC ASTHMA - NO CHANGE IN RESPIRATORY IMPEDANCE DURING INTRAESOPHAGEAL ACIDIFICATION IN ADULT ASTHMATICS

被引：25

作者：

WESSELING, G ^{[1
]}

BRUMMER, RJ ^{[1
]}

WOUTERS, EFM ^{[1
]}

TENVELDE, GPM ^{[1
]}

机构：

[1] UNIV LIMBURG HOSP, DEPT GASTROENTEROL HEPATOL, MAASTRICHT, NETHERLANDS

来源：

CHEST | 1993年 / 104卷 / 06期

关键词：

D O I：

10.1378/chest.104.6.1733

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: In patients with asthma, gastroesophageal reflux (GER) has been shown to be a common finding, and a number of investigators have suggested that reflux may have a deleterious effect in athma, either as a result of recurrent (micro)aspiration or by some form of a reflex mechanism. Aim of the Study: To measure changes in lung function in response to intraesophageal acid perfusion in asthmatics with GER. Methods: In 12 patients with bronchial asthma and complaints suggesting GER with increased reflux scores during 24-h intraesophageal pH monitoring, impedance measurements of the respiratory system using the technique of forced oscillations and spirometry were performed after intraesophageal acidification. Results: No statistically significant changes in FEV1 or in respiratory impedance were demonstrated after intraesophageal acid provocation. Conclusion: No direct effect of intraesophageal acidification on bronchomotor tone was demonstrated in asthmatics with GER.

引用

页码：1733 / 1736

页数：4

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