BETA-AMYLOID PRECURSOR PROTEIN (APP)-LIKE IMMUNOREACTIVITY IN THE HUMAN SYMPATHETIC-GANGLIA

被引：6

作者：

CALZADA, B ^{[1
]}

CABAL, A ^{[1
]}

NAVES, FJ ^{[1
]}

DELVALLE, ME ^{[1
]}

REPRESA, JJ ^{[1
]}

VEGA, JA ^{[1
]}

机构：

[1] UNIV OVIEDO,FAC MED,DEPT MORFOL & BIOL CELULAR,E-33006 OVIEDO,SPAIN

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1994年 / 76卷 / 2-3期

关键词：

SYMPATHETIC GANGLIA; BETA-AMYLOID PRECURSOR PROTEIN (APP); AGING; IMMUNOHISTOCHEMISTRY; HUMAN;

D O I：

10.1016/0047-6374(94)91588-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The localization of the beta/A4 amyloid precursor protein (APP) was studied in the human lumbar paravertebral sympathetic ganglia of subjects of different ages, free of neurologic disease, using combined immunohistochemistry and image analysis techniques (optic microdensitometry). To ascertain which cells displayed APP-like immunoreactivity (APP-LI), S-100 and neurofilament proteins were studied in parallel to label the supporting glial cells and the neuron perikarya, respectively. Specific APP-LI was observed labelling both neuron cell bodies and supporting glial cells independently of age. In ail cases, the intensity of immunostaining was stronger in glial cells than in neurons. Moreover, the intensity of APP-LI was independent of both age and neuron size. Present results provide evidence for the presence of APP-LI in the human sympathetic ganglia, and for the absence of changes in the expression of this protein, or proteins, with aging. The functional and clinical relevance of these findings remains to be clarified.

引用

页码：135 / 144

页数：10

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