LIPID-PEROXIDATION AND VITAMIN-E IN RED-BLOOD-CELLS AND PLASMA IN HEMODIALYSIS-PATIENTS UNDER RHEPO TREATMENT

被引：17

作者：

NENOV, D

PASKALEV, D

YANKOVA, T

TCHANKOVA, P

机构：

[1] Medical University, Varna

来源：

ARTIFICIAL ORGANS | 1995年 / 19卷 / 05期

关键词：

LIPID PEROXIDATION; RECOMBINANT HUMAN ERYTHROPOIETIN THERAPY; ANEMIA;

D O I：

10.1111/j.1525-1594.1995.tb02355.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Lipid peroxidation, measured by malonyldialdehyde (MDA) and vitamin E in red blood cells (RBC) and plasma, was investigated in 25 hemodialysis (HD) patients before and after 6 months rhEPO therapy. RBC-MDA was significantly elevated, but plasma MDA was in the reference range. After recombinant human erythropoietin (rhEPO) treatment, the MDA level was significantly decreased in both compartments. Marked vitamin E deficiency was established in RBC as well as in plasma. rhEPO therapy restored vitamin E levels in both compartments. Our data suggest a possible positive rhEPO-antioxidant effect in HD patients.

引用

页码：436 / 439

页数：4

共 23 条

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