DIET-INDUCED CHANGES IN SUBCUTANEOUS ADIPOSE-TISSUE BLOOD-FLOW IN MAN - EFFECT OF BETA-ADRENOCEPTOR INHIBITION

The effect of a carbohydrate-rich meal on subcutaneous adipose tissue blood flow was studied with and without continuous i.v. infusion of propranolol in healthy volunteers. The subcutaneous adipose tissue blood flow was measured with the 133Xe washout method in three different locations: the forearm, the thigh and the abdomen. The subjects were given a meal consisting of white bread, jam, honey and apple juice (about 2300 kJ). The meal induced a twofold increase in blood flow in the examined tissues. Propranolol abolished the flow increase in the thigh and the abdomen and reduced it in the forearm. This indicates that the mechanism for the flow increase is elicited by a stimulation of vascular β-adrenoceptors in the subcutaneous adipose tissue, since the β-adrenoceptor inhibition did not affect the overall metabolic and hormonal responses to the meal.