COCAINE PLACE PREFERENCE IS BLOCKED BY THE DELTA-OPIOID RECEPTOR ANTAGONIST, NALTRINDOLE

被引：106

作者：

MENKENS, K

BILSKY, EJ

WILD, KD

PORTOGHESE, PS

REID, LD

PORRECA, F

机构：

[1] UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT PHARMACOL,TUCSON,AZ 85724

[2] UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT PHARMACOL,TUCSON,AZ 85724

[3] RENSSELAER POLYTECH INST,DEPT PSYCHOL,TROY,NY 12180

[4] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55455

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 219卷 / 02期

关键词：

COCAINE; PLACE PREFERENCE; NALTRINDOLE;

D O I：

10.1016/0014-2999(92)90319-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Naltrindole, a selective delta-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCI (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.

引用

页码：345 / 346

页数：2

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