OPIOIDERGIC MODULATION OF COCAINE CONDITIONED PLACE PREFERENCES

被引：63

作者：

BILSKY, EJ ^{[1
]}

MONTEGUT, MJ ^{[1
]}

DELONG, CL ^{[1
]}

REID, LD ^{[1
]}

机构：

[1] RENSSELAER POLYTECH INST,DEPT PSYCHOL,TROY,NY 12180

来源：

LIFE SCIENCES | 1992年 / 50卷 / 14期

关键词：

D O I：

10.1016/0024-3205(92)90105-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent studies have begun to assess the utility of opioid agonists and antagonists for the treatment of cocaine addiction. The present studies assess the effects of naltrexone or methadone on cocaine's reinforcing properties using the conditioned place preference (CPP) test. The results indicate that a 56 mg/kg dose of naltrexone, given 4 hr prior to conditioning, attenuates cocaine's CPP. In contrast, methadone (8 mg/kg), given 1 hr prior to conditioning, enhanced cocaine's reinforcing properties. These results support the suggestion that opioid antagonists may have clinical utility in treating cocaine addiction. The results with methadone lead to a possible explanation for the higher rates of cocaine use in methadone-treated heroin addicts.

引用

页码：PL85 / PL90

页数：6

共 18 条

[1]

BAIN GT, 1990, OPIOIDS, BULIMIA, AND ALCOHOL ABUSE & ALCOHOLISM, P73

[2] MDL72222, A SEROTONIN 5-HT3 RECEPTOR ANTAGONIST, BLOCKS MDMAS ABILITY TO ESTABLISH A CONDITIONED PLACE PREFERENCE [J].