STRUCTURAL BASIS FOR THE DIFFERENTIAL RXR AND RAR ACTIVITY OF STILBENE RETINOID ANALOGS

被引：35

作者：

BEARD, RL

GIL, DW

MARLER, DK

HENRY, E

COLON, DF

GILLETT, SJ

AREFIEG, T

BREEN, TS

KRAUSS, H

DAVIES, PJA

CHANDRARATNA, RAS

机构：

[1] ALLERGAN PHARMACEUT INC,DEPT CHEM,RETINOID RES,IRVINE,CA 92715

[2] ALLERGAN PHARMACEUT INC,DEPT BIOL,IRVINE,CA 92715

[3] UNIV TEXAS,SCH MED,DEPT PHARMACOL,HOUSTON,TX 77225

[4] UNIV TEXAS,SCH MED,DEPT MED,HOUSTON,TX 77225

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80511-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Retinoids elicit their biological actions by activating nuclear receptors that regulate gene transcription. There are six known retinoid receptors which belong to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families. We report RXR-active stilbene retinoid analogs and discuss the structural features that impart RAR and RXR activation properties to compounds of this class.

引用

页码：1447 / 1452

页数：6

共 44 条

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