SYNTHESIS, CHARACTERIZATION AND BIODISTRIBUTION OF NEW TC-99M OXO AND NITRIDO COMPLEXES WITH BIDENDATE AND TETRADENDATE UNSATURATED NS AND N2S2 SCHIFF-BASES DERIVED FROM 2-AMINOCYCLOPENTENE-1-DITHIOCARBOXYLIC ACID AS POTENTIAL HEART IMAGING AGENTS

被引：13

作者：

COULAIS, Y

CROS, G

DARBIEU, MH

TAFANI, JAM

BELHADJTAHAR, H

BELLANDE, E

PASQUALINI, R

GUIRAUD, R

机构：

[1] FAC MED TOULOUSE,BIOPHYS & MED NUCL LAB,F-31062 TOULOUSE,FRANCE

[2] UNIV PAUL SABATIER,CNRS,UP 8241,CHIM COORDINAT LAB,F-31077 TOULOUSE,FRANCE

[3] INST NATL POLYTECH TOULOUSE,F-31077 TOULOUSE,FRANCE

[4] CIS BIO INT,F-91192 GIF SUR YVETTE,FRANCE

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1994年 / 21卷 / 02期

关键词：

D O I：

10.1016/0969-8051(94)90018-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The synthesis, characterization and Tc-99m labelling of unsaturated diamino dithiol ligands with methyl dithiocarboxylate functions: 2-aminocyclopentene-1-dithiocarboxylic methyl ester (H(2)L1), N,N'-ethylene bis (methyl 2-aminocyclopentene-1-dithiocarboxylate) (H(2)L2) and N,N'-propylene bis (methyl 2-aminocyclopentene-1-dithiocarboxylate) (H(2)L3) are described. Cationic oxo (Tc=0) and neutral nitrido (Tc=N) complexes were obtained. Biodistribution studies in rat showed a good heart uptake of (TcN)-Tc-99m-L2 (2% ID at 5 min) with a high heart-to-blood ratio (5.8 at 5 min), but this complex also exhibited high lung and liver uptake.

引用

页码：263 / 268

页数：6