CYCLOSPORINE-A BLOCKS INDUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA IN HUMAN B-LYMPHOCYTES

被引:12
作者
SMITH, CS
ORTEGA, G
PARKER, L
SHEARER, WT
机构
[1] BAYLOR COLL MED,DEPT MICROBIOL & IMMUNOL,HOUSTON,TX 77030
[2] BAYLOR COLL MED,DEPT PEDIAT,HOUSTON,TX 77030
关键词
D O I
10.1006/bbrc.1994.2470
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of cyclosporin A (CSP) on tumor necrosis factor-alpha (TNF-alpha) RNA levels and protein production in human B cells and a B cell line were studied. The ability of CSP to block induction of RNA was compared to its inhibition of protein production in response to anti-igM, phorbol ester (PMA) and platelet-activating factor (PAF). PAF is a phospholipid which has recently been found to activate human B cells. CSP blocks PAF-induced TNF-alpha RNA-from the Ramos cell line, as well as inhibiting the enhancement of TNF protein production from both freshly isolated and Ramos B cells. CSP also blocks anti-lg induced TNF-alpha RNA and protein but does not inhibit PMA-induced TNF-alpha. We conclude that B cells, like T cells, have CSP-independent and CSP-dependent signaling pathways and that PAF signaling is dependent upon a CSP-sensitive factor. (C) 1994 Academic Press, Inc.
引用
收藏
页码:383 / 390
页数:8
相关论文
共 20 条
  • [11] MAZER B, 1991, J IMMUNOL, V146, P1914
  • [12] A NEW METHOD FOR DETACHMENT OF DYNABEADS FROM POSITIVELY SELECTED LYMPHOCYTES-B
    RASMUSSEN, AM
    SMELAND, EB
    ERIKSTEIN, BK
    CAIGNAULT, L
    FUNDERUD, S
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1992, 146 (02) : 195 - 202
  • [13] OKADAIC ACID IS A POTENT INDUCER OF AP-1, NF-KAPPA-B, AND TUMOR-NECROSIS-FACTOR-ALPHA IN HUMAN B LYMPHOCYTES
    RIECKMANN, P
    THEVENIN, C
    KEHRL, JH
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 187 (01) : 51 - 57
  • [14] SCHULAM PG, 1991, J IMMUNOL, V146, P1642
  • [15] ACTIVATION OF NF-KAPPA-B AND IMMUNOGLOBULIN EXPRESSION IN RESPONSE TO PLATELET-ACTIVATING-FACTOR IN A HUMAN B-CELL LINE
    SMITH, CS
    SHEARER, WT
    [J]. CELLULAR IMMUNOLOGY, 1994, 155 (02) : 292 - 303
  • [16] SMITH CS, 1994, IN PRESS J IMMUNOL
  • [17] PRODUCTION OF TUMOR NECROSIS FACTOR CACHECTIN BY HUMAN B-CELL LINES AND TONSILLAR B-CELLS
    SUNG, SSJ
    JUNG, LKL
    WALTERS, JA
    CHEN, W
    WANG, CY
    FU, SM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (05) : 1539 - 1551
  • [18] THOMSON A, 1993, T CELL DIRECTED IMMU, P26
  • [19] VONGRAFFENRIED B, 1989, CYCLOSPORIN MODE ACT, P213
  • [20] XIA HZ, 1993, BLOOD, V82, P2806