ANTAGONISTS OF N-METHYL-D-ASPARTATE RECEPTORS PARTIALLY PREVENT THE DEVELOPMENT OF COCAINE SENSITIZATION

被引:37
作者
HARACZ, JL
BELANGER, SA
MACDONALL, JS
SIRCAR, R
机构
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT,BRONX,NY 10461
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY 10461
[3] FORDHAM UNIV,DEPT PSYCHOL,BRONX,NY 10458
关键词
D-CPPENE; COCAINE; DIZOCILPINE; N-METHYL-D-ASPARTATE; SENSITIZATION;
D O I
10.1016/0024-3205(95)02229-C
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Behavioral sensitization to cocaine was tested for in rats pretreated with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, or D-3-(2-carboxypiperazin-4-yl)- 1-propenyl-1-phosphonic acid (D-CPPene), a competitive NMDA antagonist. A 5-day regimen of once-daily cocaine (15 mg/kg) injections yielded sensitization to cocaine (15 mg/kg)-induced behavioral activation. Cocaine sensitization was partially prevented by MK-801 (0.25 mg/kg) or D-CPPene (20 mg/kg) pretreatment. These results differ from previous reports that NMDA receptor antagonists completely prevented the development of stimulant sensitization. While raising questions about methodological differences among laboratories studying this issue, our findings suggest that sensitization may involve mechanisms dependent on NMDA-receptor function as well as NMDA receptor-independent mechanisms.
引用
收藏
页码:2347 / 2357
页数:11
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