DETERMINATION OF FURAZOLIDONE IN PORCINE TISSUE USING THERMOSPRAY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AND A STUDY OF THE PHARMACOKINETICS AND STABILITY OF ITS RESIDUES

被引：116

作者：

MCCRACKEN, RJ ^{[1
]}

BLANCHFLOWER, WJ ^{[1
]}

ROWAN, C ^{[1
]}

MCCOY, MA ^{[1
]}

KENNEDY, DG ^{[1
]}

机构：

[1] DEPT AGR NO IRELAND,DIV VET SCI,BELFAST BT4 3SD,ANTRIM,NORTH IRELAND

来源：

ANALYST | 1995年 / 120卷 / 09期

关键词：

FURAZOLIDONE; RESIDUE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PIG; PORCINE TISSUE;

D O I：

10.1039/an9952002347

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method is presented for the detection of he nitrofuran, furazolidone, in porcine tissue. Following methanol-buffer extraction of the tissue, liquid partitioning, and solid-phase clean-up, samples are analysed by using thermospray LC-MS monitoring the positive ion m/z 243 with filament-assisted ionization. The LOD is 1 mu g kg(-1). The assay is used to investigate the depletion of furazolidone from tissue and sample stability post mortem. It is necessary to snap-freeze samples by immersion in liquid nitrogen immediately-upon collection in order to improve the stability of residues in tissue.

引用

页码：2347 / 2351

页数：5

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