ENZYMES IN ORGANIC SYNTHESIS. 10. DOUBLE ENANTIOSELECTION BY A LIPASE-CATALYZED TRANSESTERIFICATION OF A MESO-DIOL WITH A RACEMIC CARBOXYLIC ESTER

被引：12

作者：

THEIL, F

KUNATH, A

SCHICK, H

机构：

[1] Centre of Selective Organic Synthesis, D(O)- 1199 Berlin-Adlershof

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)92662-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The doubly enantioselective lipase-catalyzed transesterification of the meso-diol 1 with rac-2,2,2-trifluoroethyl 2-chloropropanoate (2) afforded mainly the diastereomers 3a and 3c in a ratio depending on the origin of the lipase. Both compounds were obtained with very high e.e.'s.

引用

页码：3457 / 3460

页数：4

共 13 条

[1]

BOHLAND W, 1991, SYNTHESIS-STUTTGART, P1049

[2] ENZYMATIC-SYNTHESIS OF AMIDES WITH 2 CHIRAL CENTERS [J].