POLY(VINYL ALCOHOL) HYDROGELS AS SOFT CONTACT-LENS MATERIAL

被引:243
作者
HYON, SH
CHA, WI
IKADA, Y
KITA, M
OGURA, Y
HONDA, Y
机构
[1] KYOTO UNIV,FAC MED,BIOMED ENGN RES CTR,SAKYO KU,KYOTO 606,JAPAN
[2] KYOTO UNIV,FAC MED,DEPT OPHTHALMOL,SAKYO KU,KYOTO 606,JAPAN
关键词
POLY(VINYL ALCOHOL); HYDROGEL; SOFT CONTACT LENS; PROTEIN ADSORPTION; ANIMAL TEST;
D O I
10.1163/156856294X00103
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A new type of soft contact lens was developed from the poly(vinyl alchol) (PVA) hydrogel prepared by a low temperature crystallization technique using a water-dimethyl sulfoxide mixed solvent. The PVA contact lens materials had a water content of 78% and a tensile strength of 50 kg/cm(2), five times as strong as that of commercial poly(2-hydroxyethyl methacrylate) soft contact lens. The amount of proteins adsorbed to the PVA soft hydrogel material was half to one thirtieth of that of conventional soft contact lenses. Histological and scanning electron microscopic observation of rabbit eyes which had worn the PVA soft contact lens for 12 weeks showed no difference in corneal epithelium and cell arrangement in the corneal epithelium from the non-wearing eyes.
引用
收藏
页码:397 / 406
页数:10
相关论文
共 28 条
[11]  
HON SH, 1986, 6TH P S RAD CHEM, P657
[12]   MECHANICAL-PROPERTIES OF THE SOFT CONTACT-LENS OF POLY(METHYL METHACRYLATE-N-VINYLPYRROLIDONE) [J].
HOSAKA, S ;
YAMADA, A ;
TANZAWA, H ;
MOMOSE, T ;
MAGATANI, H ;
NAKAJIMA, A .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1980, 14 (05) :557-566
[13]  
HOSAKA S, 1980, MAKU, V5, P247
[14]  
Hyon S.H., 1989, U.S. Patent, Patent No. 4874562
[15]   PREPARATION OF TRANSPARENT POLYVINYL-ALCOHOL) HYDROGEL [J].
HYON, SH ;
CHA, WI ;
IKADA, Y .
POLYMER BULLETIN, 1989, 22 (02) :119-122
[16]   PREPARATION OF POLYVINYL-ALCOHOL) HYDROGELS BY LOW-TEMPERATURE CRYSTALLIZATION OF THE AQUEOUS POLYVINYL-ALCOHOL) SOLUTION [J].
HYON, SH ;
CHA, WI ;
IKADA, Y .
KOBUNSHI RONBUNSHU, 1989, 46 (11) :673-680
[17]  
HYON SH, 1991, SEN-I GAKKAISHI, V47, P156
[18]  
HYON SH, 1988, 3RD P WORLD BIOM C, V3, P536
[19]  
ICHIJIMA H, 1989, CLAO, V15, P290
[20]  
IJCHIJIMA H, 1992, CORNEA, V11, P282