A SECRETED CALRETICULIN PROTEIN IN IXODID TICK (AMBLYOMMA-AMERICANUM) SALIVA

被引：75

作者：

JAWORSKI, DC

SIMMEN, FA

LAMOREAUX, W

COONS, LB

MULLER, MT

NEEDHAM, GR

机构：

[1] OHIO STATE UNIV,DEPT ENTOMOL,ACAROL LAB,COLUMBUS,OH 43210

[2] UNIV FLORIDA,DEPT DAIRY & POULTRY SCI,GAINESVILLE,FL 32611

[3] UNIV FLORIDA,ANIM & CELL BIOL PROGRAM,GAINESVILLE,FL 32611

[4] MEMPHIS STATE UNIV,DEPT BIOL,CTR ELECTRON MICROSCOPY,MEMPHIS,TN 38152

[5] OHIO STATE UNIV,DEPT MOLEC GENET,COLUMBUS,OH 43210

来源：

JOURNAL OF INSECT PHYSIOLOGY | 1995年 / 41卷 / 04期

关键词：

CALRETICULIN; TICK SALIVA; ANTIHEMOSTASIS; IMMUNOSUPPRESSION;

D O I：

10.1016/0022-1910(94)00107-R

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

A complementary DNA clone from salivary glands of feeding female Amblyomma americanum ticks has been characterized as encoding calreticulin. Calreticulin, a major endoplasmic reticulum (ER) calcium-binding protein, appears to be secreted in Amblyomma and Dermacentor saliva. Evidence is accummulating that calreticulin performs roles unrelated to calcium storage, Unlike most known calreticulins, tick-secreted calreticulin lacks the ER retention signal, KDEL. This is the first molecular cloning of a specific tick salivary gland protein. The finding of a secreted calreticulin in tick saliva suggests a role for calreticulin in blood feeding through host immunosuppression or antihemostasis.

引用

页码：369 / 375

页数：7

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