BIS(S-ACYL-2-THIOETHYL)ESTERS OF 2',3'-DIDEOXYADENOSINE 5'-MONOPHOSPHATE ARE POTENT ANTI-HIV AGENTS IN CELL-CULTURE

被引：10

作者：

PERIGAUD, C

GOSSELIN, G

BENZARIA, S

GIRARDET, JL

MAURY, G

PELICANO, H

AUBERTIN, AM

KIRN, A

IMBACH, JL

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,URA 488,F-34095 MONTPELLIER 5,FRANCE

[2] UNIV STRASBOURG 1,INSERM,U74,F-67000 STRASBOURG,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012472

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC(50) values for the bis(S-acetyl-2-thioethyl)phosphotriester derivative, which makes this compound as active as AZT.

引用

页码：789 / 791

页数：3

共 5 条

[1]

Imbach J.-L., 1994, Antiviral Research, V23, P47

[2]

MCGOWAN JJ, 1990, REV INFECT DIS, V12, pS513

[3] RATIONAL DESIGN FOR CYTOSOLIC DELIVERY OF NUCLEOSIDE MONOPHOSPHATES - SATE AND DTE AS ENZYME-LABILE TRANSIENT PHOSPHATE PROTECTING GROUPS [J].