PROTEIN SPLICING - SELF-SPLICING OF GENETICALLY MOBILE ELEMENTS AT THE PROTEIN LEVEL

被引：95

作者：

COOPER, AA

STEVENS, TH

机构：

[1] Institute of Molecular Biology, University of Oregon, Eugene

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 09期

关键词：

D O I：

10.1016/S0968-0004(00)89075-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein splicing is a newly discovered process that is the protein equivalent of RNA splicing. Protein splicing proceeds through a branched protein intermediate, and in vitro studies indicate that the reaction is autocatalytic, The excised 'intein' proteins are site-specific DNA endonucleases that catalyse genetic mobility of their DNA coding sequence by an 'intein homing' mechanism.

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页码：351 / 356

页数：6

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