A NEW P-CHIRAL BISPHOSPHINE, (S,S)-1,2-BIS(O-ETHYLPHENYL)PHENYL-PHOSPHINOETHANE, AS AN EFFECTIVE LIGAND IN CATALYTIC ASYMMETRIC HYDROGENATION OF ALPHA-(ACYLAMINO)ACRYLIC ACIDS

被引：53

作者：

IMAMOTO, T

TSURUTA, H

WADA, Y

MASUDA, H

YAMAGUCHI, K

机构：

[1] OGAWA & CO LTD, OKAYAMA LAB, KATSUTA, OKAYAMA 70943, JAPAN

[2] CHIBA UNIV, CTR CHEM ANAL, INAGE, CHIBA 263, JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 45期

关键词：

D O I：

10.1016/0040-4039(95)01775-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(S,S)-1,2-Bis[(o-ethylphenyl)phenylphosphino]ethane has been prepared via optically active phosphine-boranes. Asymmetric hydrogenation of alpha-(acylamino)acrylic acids by a rhodium complex with this ligand affords N-acylamino acids in 86-93% ee.

引用

页码：8271 / 8274

页数：4