RELATIONSHIP BETWEEN PARAMETERS OF SEROTONIN TRANSPORT AND ANTIDEPRESSANT PLASMA-LEVELS OR THERAPEUTIC RESPONSE IN DEPRESSIVE PATIENTS TREATED WITH PAROXETINE AND AMITRIPTYLINE

被引：29

作者：

KUHS, H ^{[1
]}

SCHLAKE, HP ^{[1
]}

ROLF, LH ^{[1
]}

RUDOLF, GAE ^{[1
]}

机构：

[1] UNIV MUNSTER,DEPT NEUROL,W-4400 MUNSTER,GERMANY

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1992年 / 85卷 / 05期

关键词：

PAROXETINE; AMITRIPTYLINE; SEROTONIN;

D O I：

10.1111/j.1600-0447.1992.tb10320.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 [精神病与精神卫生学];

摘要：

In a double-blind clinical study, antidepressant plasma levels, parameters of platelet serotonin (5-HT) transport (K(m), V(max) and basal platelet 5-HT content) and therapeutic response were measured in depressive patients treated with either paroxetine (30 mg/day) or amitriptyline (150 mg/day) for 6 weeks. No correlation could be found between paroxetine plasma levels and therapeutic outcome after 2, 4 and 6 weeks of treatment. In contrast to the amitriptyline group, a marked increase in K(m) from baseline to week 2 was determined in paroxetine-treated patients, with K(m) increase being correlated with paroxetine plasma levels at week 2. However, no significant relationship could be found between 5-HT transport parameters and any of the outcome measures in either treatment group.

引用

页码：364 / 369

页数：6

共 27 条

[1]

EFFECTS OF ZIMELIDINE AND DESIPRAMINE ON SEROTONIN AND NORADRENALINE UPTAKE MECHANISMS IN RELATION TO PLASMA-CONCENTRATIONS AND TO THERAPEUTIC EFFECTS DURING TREATMENT OF DEPRESSION [J].