ROLES FOR MANNOSE-6-PHOSPHATE RECEPTORS IN LYSOSOMAL-ENZYME SORTING, IGF-II BINDING AND CLATHRIN-COAT ASSEMBLY

被引：84

作者：

LUDWIG, T ^{[1
]}

LEBORGNE, R ^{[1
]}

HOFLACK, B ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/S0962-8924(00)89000-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two related transmembrane proteins in mammalian cells bind the mannose 6-phosphate recognition marker present on all soluble lysosomal hydrolases. Recent studies of cells that express only one or neither of these proteins have shed light Mot only on their function in directing lysosomal enzymes into the endocytic pathway but also on their critical role in transport vesicle formation in the trans Golgi network. One of these proteins also binds insulin-like growth factor II (IGF-II) and may be an important part of the IGF-dependent system that regulates development.

引用

页码：202 / 206

页数：5

共 61 条

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