ANTITUSSIVE EFFECT OF DIHYDROETORPHINE IN MICE

被引：8

作者：

KAMEI, J ^{[1
]}

IWAMOTO, Y ^{[1
]}

SUZUKI, T ^{[1
]}

MISAWA, M ^{[1
]}

NAGASE, H ^{[1
]}

KASUYA, Y ^{[1
]}

机构：

[1] TORAY INDUSTRIES LTD,BASIC RES LABS,KAMAKURA,KANAGAWA 248,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 260卷 / 2-3期

关键词：

DIHYDROETORPHINE; COUGH; ANTITUSSIVE EFFECT; OPIOID RECEPTOR; (MOUSE);

D O I：

10.1016/0014-2999(94)90347-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study examined the opioid receptors involved in the antitussive effect of dihydroetorphine in mice. Dihydroetorphine suppressed coughs dose dependently at doses between 0.1-1 mu g/kg i.p. Blockade of mu-opioid receptors by pretreatment with beta-funaltrexamine significantly reduced the antitussive effect of dihydroetorphine. Furthermore, the antitussive effect of dihydroetorphine was also antagonized by nor-binaltorphimine, a kappa-opioid receptor antagonist. However, pretreatment with naltrindole, a delta-opioid receptor antagonist, did not affect the antitussive effect of dihydroetorphine. These results indicate that the antitussive effect of dihydroetorphine is mediated by the activation of mu-opioid receptors and of kappa-opioid receptors, but not delta-opioid receptors.

引用

页码：257 / 259

页数：3

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