IDENTIFICATION OF A RETINOIC ACID-INDUCIBLE ENDOGENOUS RETROVIRAL TRANSCRIPT IN THE HUMAN TERATOCARCINOMA-DERIVED CELL-LINE PA-1

被引：34

作者：

KANNAN, P ^{[1
]}

BUETTNER, R ^{[1
]}

PRATT, DR ^{[1
]}

TAINSKY, MA ^{[1
]}

机构：

[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT TUMOR BIOL, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 11期

关键词：

D O I：

10.1128/JVI.65.11.6343-6348.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Retinoic acid (RA), a developmental morphogen, causes activation of a transcript of an endogenous retrovirus-related element in the human teratocarcinoma-derived cell line PA-1. This provirus is defective, and the provirus-related sequences exist as multicopy elements (more than 20 copies) in human DNA. This is the first human endogenous retroviral mRNA that is known to be transcriptionally activated by RA. The nucleotide sequence of the 3,357 bp of this viral cDNA was determined and shows a strong homology to the type C-related human endogenous retroviral proviruses ERV3 and 4-1. This cDNA contains 'R-U5-DELTA-pol-env-U3-R sequences of the provirus. Adjacent to the putative 5' long terminal repeat of this provirus there is an 18-bp sequence complementary to the 3' end of isoleucine tRNA. We named this RA-responsive virus RRHERV-I.

引用

页码：6343 / 6348

页数：6

共 52 条

[31] INDEPENDENT MECHANISMS INVOLVED IN SUPPRESSION OF THE MOLONEY LEUKEMIA-VIRUS GENOME DURING DIFFERENTIATION OF MURINE TERATOCARCINOMA CELLS [J].

NIWA, O ;

YOKOTA, Y ;

ISHIDA, H ;

SUGAHARA, T .

CELL, 1983, 32 (04) :1105-1113

[32] ERV3, A FULL-LENGTH HUMAN ENDOGENOUS PROVIRUS - CHROMOSOMAL LOCALIZATION AND EVOLUTIONARY RELATIONSHIPS [J].

OCONNELL, C ;

OBRIEN, S ;

NASH, WG ;

COHEN, M .

VIROLOGY, 1984, 138 (02) :225-235

[33] THE LONG TERMINAL REPEAT SEQUENCES OF A NOVEL HUMAN ENDOGENOUS RETROVIRUS [J].

OCONNELL, CD ;

COHEN, M .

SCIENCE, 1984, 226 (4679) :1204-1206

[34] STIMULATION OF EXPRESSION OF THE HUMAN ENDOGENOUS RETROVIRUS GENOME BY FEMALE STEROID-HORMONES IN HUMAN-BREAST CANCER CELL LINE-T47D [J].

ONO, M ;

KAWAKAMI, M ;

USHIKUBO, H .

JOURNAL OF VIROLOGY, 1987, 61 (06) :2059-2062

[35] NUCLEOTIDE-SEQUENCE OF HUMAN ENDOGENOUS RETROVIRUS GENOME RELATED TO THE MOUSE MAMMARY-TUMOR VIRUS GENOME [J].

ONO, M ;

YASUNAGA, T ;

MIYATA, T ;

USHIKUBO, H .

JOURNAL OF VIROLOGY, 1986, 60 (02) :589-598

[36]

PETERLIN BM, 1988, CONTROL OF HUMAN RETROVIRUS GENE EXPRESSION, P45

[37] CHARACTERIZATION AND PARTIAL NUCLEOTIDE-SEQUENCE OF ENDOGENOUS TYPE-C RETROVIRUS SEGMENTS IN HUMAN CHROMOSOMAL DNA [J].

REPASKE, R ;

ONEILL, RR ;

STEELE, PE ;

MARTIN, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (03) :678-682

[38] NUCLEOTIDE-SEQUENCE OF A FULL-LENGTH HUMAN ENDOGENOUS RETROVIRAL SEGMENT [J].

REPASKE, R ;

STEELE, PE ;

ONEILL, RR ;

RABSON, AB ;

MARTIN, MA .

JOURNAL OF VIROLOGY, 1985, 54 (03) :764-772

[39] ANALYSIS OF A DROSOPHILA TRANSFER-RNA GENE-CLUSTER - 2 TRANSFER RNALEU GENES CONTAIN INTERVENING SEQUENCES [J].

ROBINSON, RR ;

DAVIDSON, N .

CELL, 1981, 23 (01) :251-259

[40] NUCLEOTIDE-SEQUENCE OF A MOUSE TRANSFER-RNA GENE-CLUSTER [J].

RUSSO, T ;

DUILIO, A ;

AMMENDOLA, R ;

COSTANZO, F ;

CIMINO, F .

NUCLEIC ACIDS RESEARCH, 1987, 15 (20) :8562-8562

← 1 2 3 4 5 6 →