STRUCTURES OF 9 NEW DITERPENOIDS FROM TAXUS-CHINENSIS

被引：38

作者：

FUJI, K

TANAKA, K

LI, B

SHINGU, T

YOKOI, T

SUN, HD

TAGA, T

机构：

[1] KOBE GAKUIN UNIV,FAC PHARMACEUT SCI,NISHI KU,KOBE 65121,JAPAN

[2] ACAD SINICA,KUNMING INST BOT,KUNMING 650204,PEOPLES R CHINA

[3] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 606,JAPAN

[4] KYOTO UNIV,INST CHEM RES,UJI 611,KYOTO,JAPAN

来源：

TETRAHEDRON | 1995年 / 51卷 / 37期

关键词：

D O I：

10.1016/0040-4020(95)00607-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of nine new diterpenoids from the leaves and stems of Taxus chinensis were elucidated by means of NMR spectroscopy. Some of the new diterpenes were subjected to X-ray crysta)lographic analysis. Taxchinins D, G, E, H, I, J, K have an 11(15 --> 1)-abeotaxane skeleton. Tawchins A and B possess an ordinary taxane skeleton, and belong to the first example of taxoids without an oxygen functionality or the sp(2)-hybridized carbon at C-4. Taxchinins D, E, I, and J exist as a mixture of conformational isomers in solution, whose behavior was investigated by variable-temperature NMR spectra and compared with the conformation obtained from X-ray analysis.

引用

页码：10175 / 10188

页数：14

共 20 条

[1] REVISED STRUCTURE OF BREVIFOLIOL AND SOME BACCATIN-VI DERIVATIVES [J].

APPENDINO, G ;

BARBONI, L ;

GARIBOLDI, P ;

BOMBARDELLI, E ;

GABETTA, B ;

VITERBO, D .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (20) :1587-1589

[2] TAXANES FROM THE SEEDS OF TAXUS-BACCATA [J].

APPENDINO, G ;

TAGLIAPIETRA, S ;

OZEN, HC ;

GARIBOLDI, P ;

GABETTA, B ;

BOMBARDELLI, E .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (04) :514-520

[3] BREVIFOLIOL, A TAXANE FROM TAXUS-BREVIFOLIA [J].

BALZA, F ;

TACHIBANA, S ;

BARRIOS, H ;

TOWERS, GHN .

PHYTOCHEMISTRY, 1991, 30 (05) :1613-1614

[4] CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES .16. REARRANGED TAXOIDS FROM TAXUS X MEDIA REHD CV HICKSII - X-RAY MOLECULAR-STRUCTURE OF 9-O-BENZOYL-9,10-DIDE-O-ACETYL-11(15-]1)ABEO-BACCATIN VI [J].

BARBONI, L ;

GARIBOLDI, P ;

TORREGIANI, E ;

APPENDINO, G ;

CRAVOTTO, G ;

BOMBARDELLI, E ;

GABETTA, B ;

VITERBO, D .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1994, (21) :3233-3238

[5] THE CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES .5. TAXANES FROM THE NEEDLES OF TAXUS-WALLICHIANA [J].

BARBONI, L ;

GARIBOLDI, P ;

TORREGIANI, E ;

APPENDINO, G ;

GABETTA, B ;

ZINI, G ;

BOMBARDELLI, E .

PHYTOCHEMISTRY, 1993, 33 (01) :145-150

[6] SCIENTISTS MOBILIZE TO INCREASE SUPPLY OF ANTICANCER DRUG TAXOL [J].

BORMAN, S .

CHEMICAL & ENGINEERING NEWS, 1991, 69 (35) :11-18

[7] ISOLATION AND STRUCTURE ELUCIDATION OF NEW TAXOIDS FROM TAXUS-BREVIFOLIA [J].

CHEN, R ;

KINGSTON, DGI .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (07) :1017-1021

[8]

Della Casa de Marcano D. P., 1975, J CHEM SOC CHEM COMM, P365

[9]

DEMARCANO DPD, 1970, J CHEM SOC CHEM COMM, P1381

[10] TAXCHININ-A - A DITERPENOID FROM TAXUS-CHINENSIS [J].

FUJI, K ;

TANAKA, K ;

LI, B ;

SHINGU, T ;

SUN, HD ;

TAGA, T .

TETRAHEDRON LETTERS, 1992, 33 (51) :7915-7916

← 1 2 →