CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES .16. REARRANGED TAXOIDS FROM TAXUS X MEDIA REHD CV HICKSII - X-RAY MOLECULAR-STRUCTURE OF 9-O-BENZOYL-9,10-DIDE-O-ACETYL-11(15-]1)ABEO-BACCATIN VI

被引：18

作者：

BARBONI, L

GARIBOLDI, P

TORREGIANI, E

APPENDINO, G

CRAVOTTO, G

BOMBARDELLI, E

GABETTA, B

VITERBO, D

机构：

[1] UNIV CAMERINO, DIPARTIMENTO SCI CHIM, I-62032 CAMERINO, ITALY

[2] UNIV TURIN, DIPARTIMENTO SCI & TECNOL FARMACO, I-10125 TURIN, ITALY

[3] INDENA SPA, I-20141 MILAN, ITALY

[4] UNIV TURIN, DIPARTIMENTO CHIM INORGAN CHIM FIS & CHIM MAT, I-10125 TURIN, ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 21期

关键词：

D O I：

10.1039/p19940003233

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The roots of Taxus x media Rehd. cv Hicksii gave four new taxoids of the abeo 11(15-->1)-type (2-5). Structures were elucidated by spectroscopic techniques, including X-ray analysis for compound 4. Compound 2 is conformationally fixed, whereas compounds 3-5 exist in solution as a mixture of rotamers, whose interconversion was investigated by variable-temperature NMR spectroscopy. Compound 2 has a C-13. C-15 oxygen bridge, and is the first natural taxoid with a beta-oxygen function at C-13.

引用

页码：3233 / 3238

页数：6

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