NITRIC-OXIDE SYNTHASE ACTIVITY IN GENETIC-HYPERTENSION

被引：108

作者：

MALINSKI, T ^{[1
]}

KAPTURCZAK, M ^{[1
]}

DAYHARSH, J ^{[1
]}

BOHR, D ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT PHYSIOL,ANN ARBOR,MI 48109

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1871

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A porphyrinic sensor was used to monitor nitric oxide released from cultured endothelial and vascular smooth muscle cells obtained from genetically hypertensive rats and from a normotensive reference strain of rats. Endothelial cell nitric oxide synthase (the constitutive enzyme) was stimulated with bradykinin, and vascular smooth muscle cell nitric oxide synthase (the inducible enzyme) was induced with interleukin-1β. Both types of cells from hypertensive rats released less nitric oxide than did cells from normotensive rats. The observed deficient nitric oxide release from endothelial and smooth muscle cells may contribute to the elevated vascular tone and increased cell growth described in hypertension. © 1993 Academic Press, Inc.

引用

页码：654 / 658

页数：5

共 13 条

[1] NITRIC-OXIDE ACTIVATES GUANYLATE CYCLASE AND INCREASES GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE LEVELS IN VARIOUS TISSUE PREPARATIONS [J].