A SEQUENTIAL CLINICAL-TRIAL FOR COMPARING 3 TREATMENTS

被引：19

作者：

SIEGMUND, D

机构：

来源：

ANNALS OF STATISTICS | 1993年 / 21卷 / 01期

关键词：

SEQUENTIAL TEST; BOUNDARY CROSSING PROBABILITY; REPEATED SIGNIFICANCE TEST;

D O I：

10.1214/aos/1176349037

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

A model for sequential clinical trials involving three treatments is proposed and various error probabilities are defined. A specific procedure involving a concatenation of repeated significance tests is studied in detail. The first phase of testing proceeds until at least one treatment is eliminated; and then a second phase is used to compare the remaining treatments. Analytic approximations to the operating characteristics of the test are derived and compared with the results of a Monte Carlo experiment.

引用

页码：464 / 483

页数：20

共 13 条

[1]

BETENSKY RA, 1992, THESIS STANFORD U

[2] THE 1ST-PASSAGE DENSITY OF A CONTINUOUS GAUSSIAN PROCESS TO A GENERAL BOUNDARY [J].