GAMMA-PYRONE COMPOUNDS .5. SYNTHESIS AND ANTIPLATELET EFFECTS OF XANTHONOXYPROPANOLAMINES AND RELATED-COMPOUNDS

被引：18

作者：

LIOU, SS

TENG, CM

KO, FN

LIN, CN

机构：

[1] KAOHSIUNG MED COLL,NAT PROD RES CTR,KAOHSIUNG 807,TAIWAN

[2] NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,TAIPEI 100,TAIWAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 03期

关键词：

D O I：

10.1002/jps.2600830325

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of simple xanthonoxypropanolamines and related compounds were synthesized. 3-[3-(Cyclopropylamino)propoxy]-xanthone showed same potent antiplatelet effects as norathyriol tetraacetate on arachidonate-induced aggregation. 3-[3-(Cyclohexylamino)-2-hydroxypropoxy]xanthone showed more potent antiplatelet effects than norathyriol tetraacetate on collagen-induced aggregation. The various amino groups of the oxypropanolamine or oxypropylamine side chains of the synthesized compounds regulated the antiplatelet effects.

引用

页码：391 / 395

页数：5

共 13 条

[1]

BIEMANN K, 1989, SPECTRAL DATA STRUCT, P173

[2] C-13 NMR-SPECTROSCOPY OF POLYMETHOXYXANTHONES [J].