THE N-TERMINAL CYTOPLASMIC TAIL OF THE ASPARTATE RECEPTOR IS NOT ESSENTIAL IN SIGNAL-TRANSDUCTION OF BACTERIAL CHEMOTAXIS

被引：13

作者：

CHEN, XM ^{[1
]}

KOSHLAND, DE ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,BERKELEY,CA 94720

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 41期

关键词：

D O I：

10.1074/jbc.270.41.24038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To determine the role in transmembrane signaling of the N-terminal peptide of the first transmembrane region of the aspartate receptor, it was subjected to extensive mutagenesis. Drastic changes did not alter the chemotactic ability of the receptor to aspartate significantly. Thus the cytoplasmic N terminus of the first transmembrane region does not play an essential role in transmembrane signaling, and the entire signal that is transmitted to the cytoplasmic domain must be sent through the second transmembrane region. This eliminates the models requiring an interaction of this N-terminal peptide with the remaining cytoplasmic portion of the receptor.

引用

页码：24038 / 24042

页数：5

共 30 条

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