INTERACTION BETWEEN THE ALPHA-2-NORADRENERGIC AND MUSCARINIC SYSTEMS IN THE REGULATION OF NEOCORTICAL HIGH-VOLTAGE SPINDLES

被引:34
作者
RIEKKINEN, P
SIRVIO, J
JAKALA, P
LAMMINTAUSTA, R
RIEKKINEN, P
机构
[1] UNIV KUOPIO,DEPT PATHOL,SF-70210 KUOPIO,FINLAND
[2] FARMOS GRP LTD,TURKU,FINLAND
关键词
Alpha[!sub]2[!/sub]-adrenoceptors; High voltage spindle; Interaction; Muscarinic receptors; NRT;
D O I
10.1016/0361-9230(90)90265-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present experiments were carried out in order to study the interaction between alpha2-noradrenergic and muscarinic systems in regulating high voltage spindle (HVS) activity in neocortex. Alpha2-antagonist (atipamezole 1 and 10 mg/kg) blocked HVS activity. Atipamezole at 0.1 mg/kg dose had no effect on HVS activity. Alpha2-agonist (guanfacine 0.004, 0.02 and 0.1 mg/kg) increased dose dependently HVSs. Guanfacine-induced HVSs were blocked by nucleus reticularis (NRT) lesions and by stimulation of either noradrenergic or cholinergic (pilocarpine) systems. Moreover, combined injections of atipamezole 1 mg/kg and pilocarpine 3 mg blocked HVSs more effectively than either of the drugs alone. Our results suggest that the NRT is jointly modulated by the noradrenergic and cholinergic afferents. © 1990.
引用
收藏
页码:147 / 149
页数:3
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