QUANTITATIVE IMAGING OF I-124 USING POSITRON EMISSION TOMOGRAPHY WITH APPLICATIONS TO RADIOIMMUNODIAGNOSIS AND RADIOIMMUNOTHERAPY

被引:92
作者
PENTLOW, KS
GRAHAM, MC
LAMBRECHT, RM
CHEUNG, NKV
LARSON, SM
机构
[1] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT RADIONUCLIDE & CYCLOTRON OPERAT,RIYADH 11211,SAUDI ARABIA
[2] MEM SLOAN KETTERING CANC CTR,DEPT PEDIAT,NEW YORK,NY 10021
[3] MEM SLOAN KETTERING CANC CTR,DEPT MED IMAGING,NEW YORK,NY 10021
关键词
POSITRON EMISSION TOMOGRAPHY (PET); I-124; QUANTITATIVE IMAGING; RADIOIMMUNOTHERAPY; MONOCLONAL ANTIBODY DOSIMETRY;
D O I
10.1118/1.596728
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Positron emission tomography (PET) is potentially useful for the quantitative imaging of radiolabeled antibodies, leading in turn to improved dosimetry in radioimmunotherapy. Iodine-124 is a positron-emitting nuclide with appropriate chemical properties and half-life (4.2 days) for such studies since the radiolabeling of antibodies with iodine is well understood and the half-life permits measurements over several days. Unfortunately, I-124 has a complex decay scheme with many high-energy gamma rays and a positron abundance of only 25%. It has therefore been largely ignored as a PET-imaging nuclide. However, measurements made with phantoms and animals under realistic conditions using a BGO-based PET scanner have shown that satisfactory imaging and quantitation can be achieved. Investigations of spatial resolution, the linearity of regional observed count rate versus activity in the presence of other activity, and the visualization and quantitation of activity in spheres with different surrounding background activities were carried out with phantoms up to 22 cm in diameter. Compared with F-18, spatial resolution was only slightly degraded (13.5 mm FWHM vs 12 mm FWHM) while linearity was the same over a 10:1 activity range (0.015 to 0.15 MBq/ml for I-124). The visualization and quantitation of spheres was also slightly degraded when using similar imaging times. Increasing the imaging time for I-124 reduced the difference. To verify that the technique would work in vivo, measurements were made of human neuroblastoma tumors in rats which had been injected with I-124 labeled 3F8 antibody. Although the number of samples was small, good agreement was achieved between image-based measurements and direct measurements of excised 4-g tumors. Thus quantitative imaging of I-124 labeled antibodies appears to be possible under realistic conditions.
引用
收藏
页码:357 / 366
页数:10
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