A NOVEL HECK ARYLATION REACTION - RAPID ACCESS TO CONGENERS OF FR-900482

被引：59

作者：

MCCLURE, KF ^{[1
]}

DANISHEFSKY, SJ ^{[1
]}

机构：

[1] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06511

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 14期

关键词：

D O I：

10.1021/ja00067a026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The C-6-C-7 bond of the epoxybenzazocine core of the antitumor FR 900482 series can be closed in high yield via a Heck arylation reaction of a 6-iodo-7,13-methylene seco precursor.

引用

页码：6094 / 6100

页数：7

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