A WIDELY DISTRIBUTED PUTATIVE MAMMALIAN TRANSCRIPTIONAL REGULATOR CONTAINING MULTIPLE PAIRED AMPHIPATHIC HELICES, WITH SIMILARITY TO YEAST SIN3

The mammalian Sin3 gene (mSin3) encodes four paired amphipathic helix (PAH) motifs, three of which and an extended region beyond PAH3 share between 59 and 70% sequence similarity with the yeast transcriptional regulator, SIN3. However, mSin3/SIN3 fusion proteins were not able to substitute for the yeast molecule in complementation assays. Transcripts encoding this putative transcriptional regulator, which maps to human chromosome 15q24, were detected in multiple mouse tissues, with highest levels seen in testis, lung, and thymus. Its wide tissue distribution suggests that mSin3, like yeast SIN3, may regulate the transcription of multiple genes. (C) 1995 Academic Press, Inc.