LOCAL HYPERTHERMIA ENHANCES CYCLOPHOSPHAMIDE, IFOSFAMIDE AND CIS-DIAMMINEDICHLOROPLATINUM CYTOTOXICITY ON HUMAN-DERIVED BREAST-CARCINOMA AND SARCOMA XENOGRAFTS IN NUDE-MICE

被引：48

作者：

WIEDEMANN, G ^{[1
]}

ROSZINSKI, S ^{[1
]}

BIERSACK, A ^{[1
]}

WEISS, C ^{[1
]}

WAGNER, T ^{[1
]}

机构：

[1] MED UNIV LUBECK, DEPT PHYSIOL, W-2400 LUBECK, GERMANY

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1992年 / 118卷 / 02期

关键词：

HYPERTHERMIA; CYCLOPHOSPHAMIDE; IFOSFAMIDE; CIS-DIAMMINEDICHLOROPLATINUM; INTRATUMORAL PH AND PO2; HUMAN TUMOR XENOGRAFTS;

D O I：

10.1007/BF01187501

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antitumour response and toxicity of locally applied hyperthermia with or without cyclophosphamide, ifosfamide, and cis-diamminedichloroplatinum (cisplatin) have been compared. The model systems were human breast carcinoma (MX1/3) and human sarcoma (S117) grown in nude mice. In order to detect changes of tumour oxygenation intratumoral PO2 and pH were measured before, during and following hyperthermia. In both human tumour lines a monotherapy with one of the cytotoxic drugs or with hyperthermia caused a transient growth delay, while the combination of the same dose of the drugs with hyperthermia (at 43-degrees-C for 1 h) resulted in complete tumour remissions. During hyperthermia, in both tumour types oxygenation was improved. Intratumoral pH remained practically unchanged.

引用

页码：129 / 135

页数：7