A new saxitoxin analogue from a xanthid crab Atergatis floridus

被引：33

作者：

Arakawa, O

Nishio, S

Noguchi, T

Shida, Y

Onoue, Y

机构：

[1] SHIKOKU UNIV, JR COLL, DEPT HOME ECON, FOOD CHEM LAB, TOKUSHIMA 77111, JAPAN

[2] NAGASAKI UNIV, FAC FISHERIES, LAB FOOD HYG, NAGASAKI 852, JAPAN

[3] TOKYO COLL PHARM, HACHIOJI, TOKYO 19203, JAPAN

来源：

TOXICON | 1995年 / 33卷 / 12期

关键词：

D O I：

10.1016/0041-0101(95)00106-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel paralytic toxin was isolated from toxic specimens of a xanthid crab Atergatis floridus inhabiting the Pacific coast of Shikoku Island, Its structure was deduced to be 11-saxitoxinethanoic acid (SEA) based on highperformance liquid chromatography, electrospray ionization mass spectrometry, and H-1 and C-13-NMR spectrometries. This acid was assumed to exist as an equilibrium mixture of three tautomers, the main tautomer being the hydrate form of 11 beta-epimer. SEA showed a specific toxicity of 830 mouse units per mu mole on i.p. injection into mice.

引用

页码：1577 / 1584

页数：8

共 17 条

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