INFLUENCE OF CHIRAL CARVONES ON SELECTIVITY OF PURE LIPASE-B FROM CANDIDA-ANTARCTICA

被引：9

作者：

ARROYO, M ^{[1
]}

SINISTERRA, JV ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID,FAC PHARM,DEPT ORGAN & PHARMACEUT CHEM,E-28040 MADRID,SPAIN

来源：

BIOTECHNOLOGY LETTERS | 1995年 / 17卷 / 05期

关键词：

D O I：

10.1007/BF00132022

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the esterification reaction in non-aqueous media lipase-B from Candida antarctica is stereoselective towards the R-isomer of ketoprofen in an achiral solvent such as isobutyl methyl ketone and in S(+) carvone. On the contrary, S(+) ketroprofen is esterified quicker in R(-) carvone. In addition, the esterification yield changes depending on the stereochemistry of the carvone used as solvent. The formation of disteromeric complexes (chiral solvent + chiral substrates) may explain this finding.

引用

页码：525 / 530

页数：6

共 10 条

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