DO THE K+ CHANNEL OPENERS RELAX SMOOTH-MUSCLE BY OPENING K+ CHANNELS

被引:215
作者
QUAST, U
机构
[1] Deartment of Pharmacology, University of T:Ubingen, D-72074 Tübingen
关键词
D O I
10.1016/0165-6147(93)90006-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
During the past decade, a group of chemically heterogeneous compounds known as the K+ channel openers has emerged. These compounds open a certain class of K+ channels(ATP-sensitive K+ channels) in the sarcolemma of vascular smooth muscle cells, which leads to hyperpolarization of the cell membrane and relaxation of the tissue. The mechanisms by which hyperpolarization affects smooth muscle contraction and contractility can thus be examined. Hyperpolarization induced by these K+ channel openers prevents Ca2+ entry through voltage-operated Ca2+ channels. Surprisingly, and by mechanisms not yet defined, hyperpolarization of the cell also reduces agonist-induced accumulation of inositol 1,4,5-trisphosphate (and consequently, Ca2+ mobilization from intracellular stores), and the Ca2+ sensitivity of the contractile apparatus. In addition, recent evidence reviewed here by Ulrich Quast suggests that the K+ channel openers possess further mechanisms of vasorelaxation not linked to the opening of plasmalemmal K+ channels.
引用
收藏
页码:332 / 337
页数:6
相关论文
共 45 条
  • [11] EDWARDS G, 1993, ANNU REV PHARMACOL, V33, P597, DOI 10.1146/annurev.pharmtox.33.1.597
  • [12] EDWARDS G, 1993, J PHYSL, V467, P311
  • [13] EFFECT OF RB+ ON CROMAKALIM-INDUCED RELAXATION AND ION FLUXES IN GUINEA-PIG TRACHEA
    FOSTER, KA
    ARCH, JRS
    NEWSON, PN
    SHAW, D
    TAYLOR, SG
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 222 (01) : 143 - 151
  • [14] FURUKAWA K, 1981, J PHARMACOL EXP THER, V218, P248
  • [15] EFFECTS OF RUBIDIUM ON RESPONSES TO POTASSIUM CHANNEL OPENERS IN RAT ISOLATED AORTA
    GREENWOOD, IA
    WESTON, AH
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1993, 109 (04) : 925 - 932
  • [16] COMPARISON OF THE EFFECTS OF BRL-34915 AND VERAPAMIL ON ELECTRICAL AND MECHANICAL-ACTIVITY IN RAT PORTAL-VEIN
    HAMILTON, TC
    WEIR, SW
    WESTON, AH
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1986, 88 (01) : 103 - 111
  • [17] A ROLE FOR INOSITOL 1,4,5-TRISPHOSPHATE IN THE INITIATION OF AGONIST-INDUCED CONTRACTIONS OF DOG TRACHEAL SMOOTH-MUSCLE
    HASHIMOTO, T
    HIRATA, M
    ITO, Y
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1985, 86 (01) : 191 - 199
  • [18] CLONING AND EXPRESSION OF AN INWARDLY RECTIFYING ATP-REGULATED POTASSIUM CHANNEL
    HO, K
    NICHOLS, CG
    LEDERER, WJ
    LYTTON, J
    VASSILEV, PM
    KANAZIRSKA, MV
    HEBERT, SC
    [J]. NATURE, 1993, 362 (6415) : 31 - 38
  • [20] EFFECTS OF P1060 AND APRIKALIM ON WHOLE-CELL CURRENTS IN RAT PORTAL-VEIN - INHIBITION BY GLIBENCLAMIDE AND PHENTOLAMINE
    IBBOTSON, T
    EDWARDS, G
    NOACK, T
    WESTON, AH
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (04) : 991 - 998