HEMOLYTIC-ANEMIA PROVOKED BY RECOMBINANT ALPHA-INTERFERON

被引:10
作者
TAKASE, K
NAKANO, T
HAMADA, M
SHIRAKI, K
OOHASHI, Y
KIHIRA, T
TAMEDA, Y
机构
[1] The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514
[2] Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Mie, 514
关键词
ALPHA-INTERFERON; SIDE EFFECT OF INTERFERON; HEMOLYTIC ANEMIA; METHYLPREDNISOLONE PULSE THERAPY;
D O I
10.1007/BF02349651
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A 30-year-old female with chronic hepatitis C treated with recombinant alpha-interferon developed serious hemolytic anemia after receiving 10 million units a day for 4 weeks. The results of Coombs' tests were negative before and after interferon therapy. The hemolytic anemia gradually improved after the withdrawal of recombinant alpha-interferon and the administration of methyl-prednisolone. The clinical course suggested that the recombinant alpha-interferon had provoked the hemolytic anemia.
引用
收藏
页码:795 / 797
页数:3
相关论文
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  • [1] Isaccs A., Lindenmann J., Virus interference. I. The interferons, Proceedings of the Royal Society B: Biological Sciences, 147, pp. 258-267, (1957)
  • [2] Hoofnagle J.H., Mullen K.D., Jones D.B., Et al., Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon, N Engl J Med, 315, pp. 1575-1578, (1986)
  • [3] Fentiman I.S., Thomas B.S., Balkwill F.R., Et al., Primary hypothyroidism associated with interferon therapy of breast cancer, Lancet, 1, (1985)
  • [4] Burman P., Karlsson F.A., Oberg K., Et al., Autoimmune thyroid disease in interferon-treated patients, Lancet, 2, pp. 100-101, (1985)
  • [5] Bevan P.C., Interferon-induced parotitis and epididymitis, Lancet, 2, (1985)
  • [6] McLaughlin P., Talpaz M., Quesada J.R., Et al., Immune thrombocytopenia following α-interferon therapy in patients with cancer, JAMA, 254, pp. 1353-1354, (1985)
  • [7] Ronnblom L.E., Alm G.V., Oberg K.E., Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors, Ann Intern Med, 115, pp. 178-183, (1991)
  • [8] Renault P.F., Hoofnagle J.H., Side effects of alpha interferon, Semin Liver Dis, 9, pp. 273-277, (1989)
  • [9] Akard L.P., Hoffman R., Elias L., Et al., Alpha-interferon and immune hemolytic anemia, Ann Intern Med, 105, (1986)
  • [10] Fornaciari G., Bassi C., Beltrami M., Et al., Hemolytic anemia secondary to interferon treatment for chronic B hepatitis, J Clin Gastroenterol, 13, pp. 596-597, (1991)