HEMOLYTIC-ANEMIA PROVOKED BY RECOMBINANT ALPHA-INTERFERON

被引:10
作者
TAKASE, K
NAKANO, T
HAMADA, M
SHIRAKI, K
OOHASHI, Y
KIHIRA, T
TAMEDA, Y
机构
[1] The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514
[2] Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Mie, 514
关键词
ALPHA-INTERFERON; SIDE EFFECT OF INTERFERON; HEMOLYTIC ANEMIA; METHYLPREDNISOLONE PULSE THERAPY;
D O I
10.1007/BF02349651
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A 30-year-old female with chronic hepatitis C treated with recombinant alpha-interferon developed serious hemolytic anemia after receiving 10 million units a day for 4 weeks. The results of Coombs' tests were negative before and after interferon therapy. The hemolytic anemia gradually improved after the withdrawal of recombinant alpha-interferon and the administration of methyl-prednisolone. The clinical course suggested that the recombinant alpha-interferon had provoked the hemolytic anemia.
引用
收藏
页码:795 / 797
页数:3
相关论文
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  • [11] Schattner A., Duggan D., Naparstek Y., Et al., Effects of interferon-α on the expression of a lupus idiotype in normal humans, Clin Immunol Immunopathol, 38, pp. 327-336, (1986)
  • [12] Revel M., Chebath J., Interferon-activated genes, Trends Biol Sci, 11, pp. 166-170, (1986)