MECHANISM OF SELF-TOLERANCE OF GAMMA-DELTA T-CELLS IN EPITHELIAL TISSUE

被引：54

作者：

BARRETT, TA

DELVY, ML

KENNEDY, DM

LEFRANCOIS, L

MATIS, LA

DENT, AL

HEDRICK, SM

BLUESTONE, JA

机构：

[1] UPJOHN CO,DIV CELL BIOL,KALAMAZOO,MI 49001

[2] US FDA,CTR BIOL EVALUAT & RES,DIV CYTOKINE BIOL,BETHESDA,MD 20892

[3] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093

[4] UNIV CALIF SAN DIEGO,CTR CANC,LA JOLLA,CA 92093

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1992年 / 175卷 / 01期

关键词：

D O I：

10.1084/jem.175.1.65

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/ delta-cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-gamma/delta-cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.

引用

页码：65 / 70

页数：6

共 32 条

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