THE ALPHA-ISOENZYME AND PI-ISOENZYME OF GLUTATHIONE S-TRANSFERASE IN HUMAN FETAL LUNG - INUTERO ONTOGENY COMPARED WITH DIFFERENTIATION IN LUNG ORGAN-CULTURE

被引：29

作者：

COSSAR, D

BELL, J

STRANGE, R

JONES, M

SANDISON, A

HUME, R

机构：

[1] UNIV EDINBURGH,ROYAL INFIRM,DEPT CHILD LIFE & HLTH,SIMPSON MEM MATERN PAVIL,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

[2] UNIV EDINBURGH,DEPT PATHOL,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

[3] UNIV KEELE,DEPT POSTGRAD MED,CLIN BIOCHEM & RES LAB,KEELE ST5 5BG,STAFFS,ENGLAND

[4] N STAFFORDSHIRE HOSP,CENT PATHOL LAB,STOKE ON TRENT,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1037卷 / 02期

关键词：

(Human); (Lung); Glutathione S-transferase; Isoenzyme; Organ culture;

D O I：

10.1016/0167-4838(90)90171-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyclonal antisera to the α and π isoenzymes of glutathione S-transferase have been used in immunohistochemical studies of developing human lung. In utero expression of the π set was down-regulated in distal airway cells and the first appearance of π-negative cells coincided with phenotypic differentiation. In contrast, in the early phase of fetal lung organ culture π isoenzyme was detected in all differentiated epithelial cells and only as culture progressed did focal negativity develop. The α set showed no developmental changes in utero or in organ culture. © 1990.

引用

页码：221 / 226

页数：6