A STEROID RECOGNITION SITE IS FUNCTIONALLY COUPLED TO AN EXPRESSED GABA-A-BENZODIAZEPINE RECEPTOR

被引：89

作者：

LAN, NC

CHEN, JS

BELELLI, D

PRITCHETT, DB

SEEBURG, PH

GEE, KW

机构：

[1] UNIV SO CALIF,SCH PHARM,DEPT BIOL SCI,LOS ANGELES,CA 90089

[2] UNIV HEIDELBERG,ZENTRUM MOLEK BIOL,DEPT MOLEC NEUROENDOCRINOL,W-6900 HEIDELBERG,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1990年 / 188卷 / 06期

关键词：

PREGNANE STEROIDS; GABA (ALPHA-AMINOBUTYRIC ACID); BENZODIAZEPINE RECEPTORS; RECEPTOR GENE;

D O I：

10.1016/0922-4106(90)90201-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pregnane steroids, particularly 3-alpha-hydroxylated metabolites of progesterone, are known to have rapid and profound effects on brain excitability. Recent evidence suggests that the gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor-Cl- ionophore complex may mediate these actions. The data further suggest that these steroids modulate the complex through a novel site independent of other known sites on the complex. The hypothesis that this site is on the GABA(A)-benzodiazepine receptor-Cl- ionophore complex is tested in the present study by determining its presence on transiently expressed GABA(A)-benzodiazepine receptors.

引用

页码：403 / 406

页数：4

共 10 条

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