SERUM KINETICS OF CROTOXIN FROM CROTALUS-DURISSUS-TERRIFICUS VENOM IN MICE - EVIDENCE FOR A RAPID CLEARANCE

被引：26

作者：

BARRALNETTO, M

VONSOHSTEN, RL

机构：

[1] Servico de Imunologia, Hospital Universitario Prof. Edgard Santos, Universidade Federal da Bahia

来源：

TOXICON | 1991年 / 29卷 / 4-5期

关键词：

D O I：

10.1016/0041-0101(91)90028-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We report on an ELISA for the detection of crotoxin with a detection limit of 1-3 pg/ml of sample. Cross-reactivity with other animal venoms occurred only at concentrations above 1-mu-g/ml. Serum kinetics of crotoxin were investigated in BALB/c mice after a single 10-mu-g s.c. dose of venom obtained from Crotalus durissus terrificus. Crotoxin levels were 254 +/- 141 ng/ml serum (XBAR +/- S.E.) 15 min after venom injection, 3.9 +/- 0.5 ng/ml serum at 30 min and undetectable thereafter. The rapid clearance of crotoxin from the serum suggests that the test may be unsuitable for the clinical management of envenomation victims.

引用

页码：527 / 531

页数：5

共 19 条

[11]

PUGH RNH, 1980, LANCET, P1181

[12]

Rodrigues DS, 1988, REV SOC BRAS TOXICOL, P23

[13] DETECTION OF VENOM BY ENZYME-LINKED-IMMUNOSORBENT-ASSAY (ELISA) IN PATIENTS BITTEN BY SNAKES IN THAILAND [J].